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KMID : 1123920130270040391
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Korean Journal of Oriental Physiology and Pathology
2013 Volume.27 No. 4 p.391 ~ p.399
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Comparative Study of Antioxidant abilities on Prunus yedoensis and Betula platyphylla var. japonica
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Hong Sang-Cheol
Jun Ji-Ae
Kim Dong-Hee
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Abstract
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The purpose of this study was to examine the anti-depressive effects of OnDam-Tang with addition of Linderae Radix (ODT-L) on the animal model of depression induced by chronic immobilization stress. Depression model was made by chronic immobilization stress for 2 hours for 21 days. And we performed forced swimming test, analysis of the neurotransmitter and immunohistochemical staining, measured expression levels of serotonin in the brain. ODT-L has decreased immobilization time in forced swimming test. ODT-L has increased amount of melatonin in the brain. ODT-L has increased expression levels of serotonin in the brain. ODT-L prevented damage in the hippocampal region. ODT-L has reduced the expression level of CRF receptors in in hippocampus region. These results suggest that ODT-L may have anti-depressive effects on depression.
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KEYWORD
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Betulae Cortex, Betula platyphylla Suk. var. japonica, Prunus yedoensis Matsumura, oxidative stress
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